Project
My early research focused on the study of immune responses in both tumor and maternal-fetal microenvironments.
Using systems immunology approach, I was able to demonstrate that the early immune responses to cancer and to embryo development are similar and orchestrated by
specific CD4+ T cell population called the regulatory T cells (Tregs).
Publications
1- Nehar-Belaid D, Courau T, Dérian N, Florez ML, Ruocco MG and Klatzmann D. (2016) Regulatory T cells similarly orchestrate tolerance to fetuses and tumors. The
Journal of Immunology. 196 (2) 678- 690. PMID:26643476
2- Courau T, Nehar-Belaid D, Florez LM, Levacher B, Vazquez T, Brimaud F, Bellier B and Klatzmann D. (2016) TGFβ and VEGF cooperatively control the immunotolerant
tumor environment and the efficacy of cancer immunotherapies. The Journal of Clinical Investigation Insights. 1(9):e85974. PMID:27699271. PMCID: PMC5033816